EUS examination had higher accuracy in diagnosing T stages of esophageal carcinoma patients and the MMP-9 and NGAL markers had higher expression rates in esophageal carcinoma than in normal cells, which might be associated with occurrence and development of the esophageal carcinoma. So, EUS examination could be regarded as relevant prognostic assessment indicators of MMP-9 and NGAL.

Recently, esophageal carcinoma is a common crinose tumorous disease with higher malignant degree in clinic. Morbidity rate of our nation now is about 13 cases/100,000, which covers No. 1 in the world and leads to malignant threat for human’s health. In recent years, morbidity rate is gradually prone to significant rise. Progressive dysphasia is the main clinical manifestation of esophageal carcinoma. There are more patients at early stage which is not significant. When diagnosed in clinical admission, most of carcinoma patients has developed into middle and advanced stage, losing optimum advantages of surgical treatments. Esophageal carcinoma international TNM stage standards are only applied to the patients who take surgical treatments. Now esophageal carcinoma surgery is a surgical means for large digestive tract trauma in clinic which is generally taken for the elder patients. And esophageal carcinoma surgery is thoracotomy. It is involved in neck, chest and abdominal cavity with long operation time. In addition, traction and cutting on ambient relevant tissues, extrusion for lung and hilum on surgical side and other aspects may cause different degrees of damage for bodies and trigger strong partial and systemic injuries. Therefore, there is lack of non-surgical treatment of esophageal carcinoma clinical stage standards in clinic. EUS has gradually become clinic stage gold standards of esophageal carcinoma at prior-treatment stage.

At early stage, there is no typical clinical symptom. And it’s easy to neglect. There is higher rate of missed diagnosis, difficulty in treatment, fast disease development speed and poor prognosis effect. Clinic curatverate is low and survival rate is low, so early diagnosis and treatment is key link to reduce arcinoma mortality also the focus of the current study. Therefore, seeking a detection method that can improve diagnostic rate at early stage is essential. There are studies reported that screening of highly sensitive serum tumor markers is helpful for early diagnosis and treatment and prognosis evaluation. Esophageal carcinoma has been one means of important auxiliary diagnosis and disease evaluation along with study on tumor marker. MMP-9 and NGAL, with higher specificity and used for diagnostic carcinoma and tumor marker, are helpful to regard measurement for MMP-9 and NGAL as one of auxiliary indicators of carcinoma diagnosis, disease monitoring and prognosis before diagnosis, detection and clinic.

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